Investigating the role of vitamin A in treating vocal fold hyperkeratosis
Pathophysiological profiling of vocal fold hyperkeratosis
This study is looking at how vitamin A might help people with vocal fold hyperkeratosis, a condition that can cause voice problems, by exploring safe treatment options that could improve vocal fold health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-11005729 on NIH RePORTER |
What this research studies
This research focuses on vocal fold hyperkeratosis, a condition characterized by an abnormal buildup of keratin on the vocal folds, which can lead to voice issues. The study aims to explore non-destructive treatment options by examining the role of vitamin A in maintaining epithelial health and its potential therapeutic effects. Researchers will assess the vitamin A levels and tissue samples from patients with this condition, as well as conduct experiments in a rat model to understand how vitamin A is processed in the vocal fold tissues. The goal is to establish a scientific basis for using vitamin A supplementation as a treatment for vocal fold hyperkeratosis.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with vocal fold hyperkeratosis who may benefit from alternative treatment options.
Not a fit: Patients with vocal fold hyperkeratosis who are not interested in conservative management or those who require immediate surgical intervention may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a new, non-invasive treatment option for patients suffering from vocal fold hyperkeratosis, potentially improving their vocal health and quality of life.
How similar studies have performed: Previous research has indicated the importance of vitamin A in epithelial health, suggesting that this approach may hold promise, although it is relatively novel in the context of vocal fold hyperkeratosis.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Welham, Nathan — University of Wisconsin-Madison
- Study coordinator: Welham, Nathan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.