Investigating the role of VISTA in discoid lupus erythematosus
Role of VISTA in discoid lupus erythematosus
This study is looking at how a certain immune receptor called VISTA affects discoid lupus erythematosus (DLE), a skin condition that can be uncomfortable and cause changes in appearance, to find new treatment options that might work better for patients like you.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10857158 on NIH RePORTER |
What this research studies
This research focuses on discoid lupus erythematosus (DLE), a chronic skin condition that causes significant discomfort and disfigurement. The study aims to understand the role of a specific immune receptor called VISTA in the disease's development and progression. By examining immune cells and their interactions, particularly plasmacytoid dendritic cells, the research seeks to identify potential therapeutic targets for DLE. Patients may benefit from insights that could lead to new treatment options as current therapies are often ineffective.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with discoid lupus erythematosus, particularly those who have not responded well to existing treatments.
Not a fit: Patients with other forms of lupus or autoimmune skin diseases that do not involve discoid lupus erythematosus may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of effective treatments for discoid lupus erythematosus, improving the quality of life for affected patients.
How similar studies have performed: While there is emerging research targeting immune cells in DLE, the specific role of VISTA in this context is still being explored, making this a novel investigation.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Vesely, Matthew D — Yale University
- Study coordinator: Vesely, Matthew D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.