Investigating the role of vaginal microbiome in preterm birth
A large scale investigation of the vaginal metagenome and metabolome and their role in spontaneous preterm birth
['FUNDING_R01'] · COLUMBIA UNIVERSITY HEALTH SCIENCES · NIH-10892059
This study is looking at how the bacteria in the vagina might affect the risk of early birth in pregnant women, with the hope of finding ways to help those who are at risk.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLUMBIA UNIVERSITY HEALTH SCIENCES (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10892059 on ClinicalTrials.gov |
What this research studies
This research explores how the vaginal microbiome may contribute to spontaneous preterm birth (sPTB), a significant cause of neonatal complications. By analyzing vaginal swabs collected from a large and diverse group of pregnant women at different stages of pregnancy, the study aims to identify specific microbial patterns and their functional roles. The approach involves advanced sequencing techniques to profile the microbiome and metabolome, providing insights into the biological mechanisms that may lead to sPTB. The findings could help in developing predictive tools and therapeutic strategies for at-risk pregnancies.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant women from diverse backgrounds, particularly those with a history of spontaneous preterm birth or at risk for it.
Not a fit: Patients who are not pregnant or those who have no history of preterm birth may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for predicting and potentially preventing spontaneous preterm births.
How similar studies have performed: Previous studies have indicated a correlation between the vaginal microbiome and adverse pregnancy outcomes, suggesting that this approach may yield valuable insights.
Where this research is happening
NEW YORK, UNITED STATES
- COLUMBIA UNIVERSITY HEALTH SCIENCES — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KOREM, TAL — COLUMBIA UNIVERSITY HEALTH SCIENCES
- Study coordinator: KOREM, TAL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.