Investigating the role of USP11 in tau regulation and Alzheimer's disease
Deubiquitinase USP11 in tau regulation and age-related tauopathy
This study is looking at how a protein called USP11 affects another protein linked to Alzheimer's disease, called tau, by using mice and human brain samples, to help us understand how these proteins interact and what that means for brain health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10814242 on NIH RePORTER |
What this research studies
This research focuses on understanding how the protein USP11 affects tau, a key protein involved in Alzheimer's disease. By studying mouse models and human brain tissues, the researchers aim to uncover how USP11 influences tau's stability and aggregation, which are critical factors in the development of neurodegenerative diseases. The approach includes various advanced techniques such as imaging, biochemical assays, and behavioral studies to explore the relationship between USP11 and tau pathology across different ages and sexes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for or diagnosed with Alzheimer's disease, particularly those with age-related cognitive decline.
Not a fit: Patients with tauopathies unrelated to Alzheimer's disease or those without cognitive impairments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating Alzheimer's disease by targeting tau regulation.
How similar studies have performed: Previous research has shown promising results in targeting tau pathology, suggesting that this approach could yield significant insights into Alzheimer's disease.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Kang, David E — Case Western Reserve University
- Study coordinator: Kang, David E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.