Investigating the role of tweety genes in development and tissue health
Official title: Molecular Analysis of Tweety Family Genes in Development and Tissue Homeostasis
Funded at College of William and Mary · NIH-10806487 · Data updated 2026-11-12
This study is looking at a group of genes called the tweety gene family to see how they help keep our cells healthy and support the development of the nervous system, which could lead to new insights for people with conditions like Alzheimer's and certain cancers.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | College of William and Mary NIH-funded |
| Lab location | 1 site (Williamsburg, United States) |
| Project start | September 20, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $452,100 |
| NIH project number | 1R15HD114135-01 |
| Project ID | NIH-10806487 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals affected by Alzheimer's disease or related neurodegenerative conditions.
✕Less likely to help
Patients with non-neurological conditions or those not affected by Alzheimer's disease may not receive any benefit from this research.
What this research studies
This research focuses on understanding the tweety gene family, which is important for maintaining cell volume and has distinct roles in the development of the nervous system. By conducting experiments that manipulate the expression of these genes, researchers aim to uncover their functions during embryonic development and in adult tissue homeostasis. The study will utilize various methodologies, including gain-of-function and loss-of-function experiments, to explore how these genes contribute to regenerative responses in the body. Patients may benefit from insights gained about the tweety genes' involvement in diseases like Alzheimer's and aggressive cancers.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for conditions like Alzheimer's disease and certain cancers.
How similar studies have gone: While the tweety gene family has been implicated in various diseases, this specific investigation into their roles in human development and disease is relatively novel.
Where this research is happening
-
College of William and Mary
Williamsburg, United States Active
Researchers
- Principal investigator: Saha, Margaret S — College of William and Mary
- Study coordinator: Saha, Margaret S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.