Investigating the role of TSPAN14 in heart disease
Official title: Tspan14 expression and function in cardiovascular disease
Funded at Ut Southwestern Medical Center · NIH-11134863 · Data updated 2026-11-12
This study is looking at how differences in our genes might influence a protein called TSPAN14, which could help us understand the risk of heart disease, especially coronary artery disease, and it's for anyone interested in how genetics can affect heart health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | September 16, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $249,000 |
| NIH project number | 4R00HL163411-03 |
| Project ID | NIH-11134863 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a genetic predisposition to coronary artery disease or those who have been diagnosed with CAD.
✕Less likely to help
Patients without any genetic risk factors for coronary artery disease may not benefit from this research.
What this research studies
This research focuses on understanding how genetic variations affect the expression of TSPAN14, a protein that may play a crucial role in coronary artery disease (CAD). By analyzing specific genetic elements and their influence on TSPAN14 in vascular cells and monocytes, the study aims to uncover how these interactions contribute to CAD risk. The researchers will utilize advanced genetic and molecular techniques to explore the functions of TSPAN14 and its potential protective effects against heart disease.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating coronary artery disease by targeting TSPAN14 expression.
How similar studies have gone: Previous research has shown promising results in understanding genetic factors in coronary artery disease, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Lee-Kim, Vivian — Ut Southwestern Medical Center
- Study coordinator: Lee-Kim, Vivian
Related research
Other NIH-funded projects on the same topics.
-
Understanding how genetic changes in blood cells relate to heart disease in people with HIV
A study will look at how age-related blood cell mutations and large chromosomal changes might contribute to heart disease risk in people living with HIV.
-
Food allergy antibodies linked to heart disease risk in adults
Many adults have antibodies to foods without symptoms, and this study asks whether those antibodies are linked to higher risk of heart disease and related conditions.
-
Mindfulness training to lower cardiovascular risk for moms and babies during pregnancy
A mindfulness program is being tested during pregnancy to help prevent high blood pressure and heart problems for mothers and their babies.
-
Integrating clinical pharmacists into HIV care to reduce cardiovascular disease in people with HIV
A pharmacist-led program in HIV care aims to prevent and manage heart disease risks like high blood pressure, diabetes, and high cholesterol in people living with HIV.
-
Integrating heart care into HIV services in Botswana using statins
This project tests a simple, scalable approach to help people with HIV in Botswana start and stay on statin therapy to prevent heart attacks and strokes.
-
A heart-healthy program for aging HIV patients using therapy pets to help blood pressure
A study tests whether using the human-animal bond from dog ownership can help older adults living with HIV control their blood pressure and improve heart health.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.