Investigating the role of TRPM8 in eye health and dry eye disease
TRPM8 in eye health and disease
This study is looking at a special receptor in the eye that helps with hydration and pain, to find new ways to treat dry eye disease and make life more comfortable for people who suffer from it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-11056901 on NIH RePORTER |
What this research studies
This research focuses on dry eye disease (DED), a condition that causes discomfort and visual disturbances due to a loss of tear film stability. The study aims to explore the role of a specific receptor, TRPM8, which is involved in eye hydration and pain sensation. By understanding how TRPM8 interacts with various compounds, researchers hope to develop new treatments for DED. The approach includes advanced techniques such as structural biology and animal models to identify effective therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing symptoms of dry eye disease, particularly older adults and women who are more frequently affected.
Not a fit: Patients with other ocular conditions unrelated to dry eye disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve the quality of life for patients suffering from dry eye disease.
How similar studies have performed: Previous research has shown promise in targeting similar receptors for ocular conditions, indicating potential for success in this novel approach.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Lee, Seok-Yong — Duke University
- Study coordinator: Lee, Seok-Yong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.