Investigating the role of tRNA in autoimmune muscle and lung disease
Explore the involvement of tRNA in the pathophysiology of antisynthetase syndrome
This study is looking into how certain proteins in the body might play a role in antisynthetase syndrome, a condition that affects your muscles and lungs, to help find better treatments for people living with it.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10889843 on NIH RePORTER |
What this research studies
This research focuses on antisynthetase syndrome (ASSD), a chronic autoimmune disorder that affects muscles and lungs. It aims to understand how certain enzymes, known as aminoacyl-tRNA synthetases, and their interaction with tRNA may contribute to the disease. By studying relevant cells and creating a new animal model, the researchers hope to uncover the mechanisms behind the autoimmune response and inflammation in ASSD. This could lead to new insights into potential treatments for patients suffering from this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with antisynthetase syndrome, particularly those exhibiting symptoms like myositis and interstitial lung disease.
Not a fit: Patients without autoimmune disorders or those not diagnosed with antisynthetase syndrome may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for patients with antisynthetase syndrome.
How similar studies have performed: While the specific role of tRNA in antisynthetase syndrome is relatively novel, similar research has shown promise in understanding autoimmune diseases through the study of related mechanisms.
Where this research is happening
La Jolla, United States
- Scripps Research Institute, the — La Jolla, United States (Active)
Researchers
- Principal investigator: Yang, Xiang-Lei — Scripps Research Institute, the
- Study coordinator: Yang, Xiang-Lei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.