Investigating the role of tRNA-derived RNAs in aging
Official title: tRNA-derived short and long RNAs in aging
Funded at University of Alabama at Birmingham · NIH-10998836 · Data updated 2026-11-12
This study is looking at how certain tiny RNA molecules from tRNA might affect aging in yeast, and by changing their levels, researchers hope to learn more about how they influence lifespan and cell health, which could help us understand aging better.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | July 15, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $239,338 |
| NIH project number | 1R21AG085888-01A1 |
| Project ID | NIH-10998836 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals interested in the biological mechanisms of aging and those who may have age-related health concerns.
✕Less likely to help
Patients with acute conditions unrelated to aging or those not interested in biological research may not benefit from this research.
What this research studies
This research explores how specific short and long RNAs derived from tRNA may influence aging processes. By studying yeast, researchers will analyze changes in these RNA molecules as the organism ages, focusing on their potential roles in lifespan and cellular health. The project involves manipulating the levels of these RNAs to observe their effects on aging and the maintenance of cellular functions. This could provide insights into the biological mechanisms of aging and how they might be targeted for health benefits.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for promoting healthy aging and extending lifespan.
How similar studies have gone: While research on aging has been extensive, the specific focus on tRNA-derived RNAs is relatively novel and has not been widely tested.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Dutta, Anindya — University of Alabama at Birmingham
- Study coordinator: Dutta, Anindya
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.