Investigating the role of transfer RNAs in cancer treatment and diagnosis
Transfer RNA sequencing and application to cancer research and clinics
This study is looking at how tiny molecules called transfer RNAs (tRNAs) play a role in colorectal cancer, with the hope of finding new ways to help doctors better understand and treat the disease, especially for patients who don’t respond well to current chemotherapy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10890690 on NIH RePORTER |
What this research studies
This research focuses on understanding how transfer RNAs (tRNAs) contribute to cancer biology, particularly in colorectal cancer. By utilizing a novel high-throughput sequencing technology called Multiplex Small RNA-seq, the study aims to analyze tRNA profiles in clinical samples. This approach could help identify new cancer-related biomarkers and improve patient categorization for chemotherapy, which is currently ineffective for many patients. The research also explores the interactions between tumors and gut bacteria, providing insights into cancer progression and treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients diagnosed with colorectal cancer who are undergoing or considering chemotherapy.
Not a fit: Patients with cancers other than colorectal cancer or those who are not candidates for chemotherapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized cancer treatments, particularly for colorectal cancer patients.
How similar studies have performed: Other research has shown promise in utilizing RNA sequencing technologies for cancer diagnostics, indicating that this approach could yield significant insights.
Where this research is happening
Chicago, United States
- University of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Pan, Tao — University of Chicago
- Study coordinator: Pan, Tao
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.