Investigating the role of TMEM106B in brain aging and neurodegenerative diseases
Function of TMEM106B in Neurodegeneration
This study is looking at how a protein called TMEM106B affects brain aging and diseases like Alzheimer's and frontotemporal dementia, and it's for anyone interested in understanding how these conditions develop and how we might improve brain health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project ID | NIH-11051794 on NIH RePORTER |
What this research studies
This research focuses on understanding how the protein TMEM106B affects brain aging and contributes to neurodegenerative diseases like Alzheimer's and frontotemporal dementia. The researchers will explore the cellular functions of TMEM106B, particularly its role in lysosome transport and autophagy, which are crucial for maintaining healthy brain function. By studying mice with TMEM106B deficiencies, they aim to uncover the mechanisms behind myelination defects and the accumulation of harmful proteins in the brain. This could lead to new insights into how neurodegenerative diseases develop and progress.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for or diagnosed with neurodegenerative diseases, particularly those with a family history of Alzheimer's or frontotemporal dementia.
Not a fit: Patients with neurodegenerative diseases unrelated to TMEM106B or those in advanced stages of these conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating or preventing neurodegenerative diseases.
How similar studies have performed: Previous research has shown promising results in understanding the role of lysosomal proteins in neurodegeneration, suggesting that this approach could yield valuable insights.
Where this research is happening
Ithaca, United States
- Cornell University — Ithaca, United States (Active)
Researchers
- Principal investigator: Hu, Fenghua — Cornell University
- Study coordinator: Hu, Fenghua
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.