Investigating the role of the sinus microbiome in chronic rhinosinusitis
Official title: CRS Microbiome: Multi-omic Integrative Longitudinal Experimental (CRS-MILE) study
Funded at Indiana University Indianapolis · NIH-10988296 · Data updated 2026-11-12
This study is looking at how the germs in your sinuses might affect chronic rhinosinusitis (CRS) symptoms, with the hope of finding better ways to help you feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | November 16, 2023 |
| Project end | October 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $567,649 |
| NIH project number | 5R01AI175239-02 |
| Project ID | NIH-10988296 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with chronic rhinosinusitis who experience persistent symptoms despite standard treatments.
✕Less likely to help
Patients with acute sinus infections or those without a diagnosis of chronic rhinosinusitis may not benefit from this research.
What this research studies
This research focuses on chronic rhinosinusitis (CRS), a condition that significantly impacts quality of life. It aims to understand how changes in the sinus microbiome contribute to the inflammation and persistence of CRS symptoms. By using a multi-omic approach, the study will analyze the functional capacity of the microbiome and its interactions with the host. The findings could lead to new therapeutic strategies for managing CRS more effectively.
Why it matters
Potential benefit: If successful, this research could provide new insights and treatment options for patients suffering from chronic rhinosinusitis.
How similar studies have gone: Previous research has shown promising results in understanding the microbiome's role in chronic diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: Ramakrishnan, Vijay — Indiana University Indianapolis
- Study coordinator: Ramakrishnan, Vijay
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.