Investigating the role of the plasminogen activator pathway in lymphatic malformations
Official title: Plasminogen Activator Pathway in Lymphatic Malformations
Funded at University of South Florida · NIH-10902972 · Data updated 2026-11-12
This study is looking at how changes in the KRAS gene might affect the lymphatic system in people with lymphatic malformations, with the hope of finding new ways to treat conditions like lymphedema and chylothorax.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project start | August 16, 2024 |
| Project end | August 15, 2026 |
| Funding year | 2024 |
| Award (this year) | $39,186 |
| NIH project number | 1F31HL174150-01 |
| Project ID | NIH-10902972 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with lymphatic malformations, particularly those with associated symptoms like lymphedema or chylothorax.
✕Less likely to help
Patients without lymphatic malformations or those with unrelated conditions may not benefit from this research.
What this research studies
This research focuses on understanding how mutations in the KRAS gene affect the lymphatic system, particularly in patients with lymphatic malformations (LMs). By studying mouse models and human cells, the researchers aim to uncover the mechanisms behind the formation of lymphatic valves and how their dysfunction can lead to serious conditions like lymphedema and chylothorax. The approach includes advanced techniques such as RNA sequencing to analyze gene expression changes associated with KRAS mutations. Patients may benefit from insights that could lead to new treatment strategies for managing lymphatic disorders.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from lymphatic malformations and related complications.
How similar studies have gone: Previous research has shown promising results in understanding lymphatic malformations, but this specific approach focusing on the plasminogen activator pathway is relatively novel.
Where this research is happening
-
University of South Florida
Tampa, United States Active
Researchers
- Principal investigator: Mastrogiacomo, Diandra — University of South Florida
- Study coordinator: Mastrogiacomo, Diandra
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.