Investigating the role of the NEXMIF gene in brain development and connectivity in female mice
Official title: Study of NEXMIF mosaic expression on neuronal development and connectivity in female mice
Funded at Boston University (Charles River Campus) · NIH-10778562 · Data updated 2026-11-12
This study is looking at how a gene called NEXMIF affects brain connections in female mice, which could help us understand memory and communication problems, and possibly lead to new treatments for similar issues in people.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University (Charles River Campus) NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | February 6, 2023 |
| Project end | January 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $247,500 |
| NIH project number | 5R21MH133014-02 |
| Project ID | NIH-10778562 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include females with NEXMIF-related disorders or those exhibiting symptoms of encephalopathy.
✕Less likely to help
Patients without NEXMIF-related conditions or those not exhibiting neurological symptoms may not receive any benefit from this research.
What this research studies
This research focuses on understanding how the NEXMIF gene, which is linked to brain development issues, affects neuronal connections in female mice. By studying mice with a specific genetic makeup, researchers will analyze how variations in NEXMIF expression influence brain structure and function. The approach includes crossing genetically modified mice to visualize and assess neuronal characteristics, aiming to uncover the underlying mechanisms of communication and memory impairments associated with NEXMIF deletion. The findings could lead to new insights into potential treatments for related disorders.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential interventions for disorders related to NEXMIF dysfunction.
How similar studies have gone: While the specific focus on NEXMIF is novel, similar genetic studies have shown success in understanding other neurodevelopmental disorders.
Where this research is happening
-
Boston University (Charles River Campus)
Boston, United States Active
Researchers
- Principal investigator: Man, Hengye — Boston University (Charles River Campus)
- Study coordinator: Man, Hengye
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.