Investigating the role of the Mob4 gene in Alzheimer's disease
Official title: Mob4 activity and dysfunction in Alzheimer's Disease
Funded at University of Minnesota · NIH-10879035 · Data updated 2026-11-12
This study is looking at how a gene called Mob4, which is less active in people with Alzheimer's, affects brain cell functions, especially how they transport important materials and help with memory, to find new ways to understand and possibly treat the disease.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | July 1, 2023 |
| Project end | March 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $193,750 |
| NIH project number | 5R21AG078690-02 |
| Project ID | NIH-10879035 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk for developing it.
✕Less likely to help
Patients with other forms of dementia unrelated to Alzheimer's may not benefit from this research.
What this research studies
This research focuses on understanding how the Mob4 gene, which is significantly downregulated in Alzheimer's disease, affects neuronal functions. The study aims to explore the molecular mechanisms of Mob4 in neurons, particularly its role in regulating axonal transport and memory formation, which are critical processes impacted by Alzheimer's. By examining the interactions of Mob4 with other proteins in the STRIPAK complex, researchers hope to uncover new insights into the disease's progression and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating or preventing Alzheimer's disease by targeting the molecular pathways involving Mob4.
How similar studies have gone: While the specific role of Mob4 in Alzheimer's is being investigated for the first time, similar studies on other genes have shown promise in understanding neurodegenerative diseases.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Neisch, Amanda Louise — University of Minnesota
- Study coordinator: Neisch, Amanda Louise
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.