Investigating the role of the microbiome in Barrett's esophagus and its progression to cancer
The microbiome ecosystem of Barrett's esophagus and progression to cancer
This study is looking at how the bacteria in your gut might affect the risk of Barrett's esophagus turning into esophageal cancer, and it's for people with Barrett's esophagus who want to understand more about their condition and how to manage it better.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10656496 on NIH RePORTER |
What this research studies
This research explores how changes in the microbiome may influence the development of Barrett's esophagus (BE) and its progression to esophageal adenocarcinoma (EAC). By analyzing samples from patients with BE, some of whom progressed to EAC and others who did not, the study aims to identify specific microbiome characteristics that could be linked to cancer development. The researchers will utilize advanced computational methods to characterize these microbiomes, potentially revealing new insights into the factors that contribute to cancer risk. This could lead to improved monitoring and management strategies for patients with Barrett's esophagus.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Barrett's esophagus, particularly those who are being monitored for progression to esophageal adenocarcinoma.
Not a fit: Patients without a diagnosis of Barrett's esophagus or those who have already been diagnosed with esophageal adenocarcinoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new diagnostic tools and treatment strategies for patients at risk of developing esophageal cancer.
How similar studies have performed: Previous studies have shown promising results in understanding the role of the microbiome in various cancers, suggesting that this approach may yield valuable insights.
Where this research is happening
Seattle, United States
- Fred Hutchinson Cancer Center — Seattle, United States (Active)
Researchers
- Principal investigator: Paulson, Thomas G — Fred Hutchinson Cancer Center
- Study coordinator: Paulson, Thomas G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.