Investigating the role of the ISR pathway in dopamine neurons related to Parkinson's disease
Official title: The ISR pathway in Dopamine Neurons: Perpetrator or Protector in Parkinson's Disease
Funded at Duke University · NIH-11007180 · Data updated 2026-11-12
This study is looking at how a specific stress response in the brain affects the nerve cells that produce dopamine in people with Parkinson's disease, hoping to find new ways to help keep these cells healthy and develop better treatments for patients.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | January 1, 2024 |
| Project end | October 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $41,892 |
| NIH project number | 5F31NS136010-02 |
| Project ID | NIH-11007180 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Parkinson's disease, particularly those in advanced stages of the condition.
✕Less likely to help
Patients with early-stage Parkinson's disease or those with other movement disorders unrelated to dopamine neuron degeneration may not benefit from this research.
What this research studies
This research explores how the integrated stress response (ISR) pathway affects dopamine neurons in Parkinson's disease. It aims to understand the balance between cell survival and death in these neurons, particularly how excessive activation of the ISR may contribute to the degeneration seen in Parkinson's. By studying both human samples and mouse models, the research seeks to uncover the underlying mechanisms that lead to neuronal death and potentially identify new therapeutic targets. Patients may benefit from insights that could lead to novel treatments for this debilitating condition.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that modify the progression of Parkinson's disease.
How similar studies have gone: Previous research has shown that targeting stress response pathways can be beneficial in neurodegenerative diseases, suggesting potential for success in this approach.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Lockshin, Elana — Duke University
- Study coordinator: Lockshin, Elana
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.