Investigating the role of the immune system in Alzheimer's disease
Official title: Neuroimmune Genomic Profiling of Alzheimer's Disease
Funded at Univ of Massachusetts Med Sch Worcester · NIH-10814621 · Data updated 2026-11-12
This study is looking at how certain immune cells called T-cells might play a role in the progression of Alzheimer's disease, and it's for people with Alzheimer's who want to understand more about how their immune system interacts with the condition.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project start | September 25, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $828,534 |
| NIH project number | 1U01AG085679-01 |
| Project ID | NIH-10814621 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at high risk for developing the condition.
✕Less likely to help
Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
What this research studies
This research explores how the adaptive immune system interacts with Alzheimer's disease, particularly focusing on specific types of T-cells that may contribute to the disease's progression. By analyzing the genetic profiles of these immune cells in patients with Alzheimer's, the study aims to uncover the molecular mechanisms behind the disease's pathology. The researchers will utilize advanced assays to track T-cell receptor repertoires in both Alzheimer's patients and healthy controls, providing insights into the immune response in the aging brain.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies targeting the immune system to slow or prevent the progression of Alzheimer's disease.
How similar studies have gone: While the role of the immune system in Alzheimer's is a relatively new area of investigation, preliminary studies have shown promising results in understanding its impact on disease progression.
Where this research is happening
-
Univ of Massachusetts Med Sch Worcester
Worcester, United States Active
Researchers
- Principal investigator: Rogaev, Evgeny I — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Rogaev, Evgeny I
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.