Investigating the role of the HDAC3 pathway in lung cancer with LKB1 mutations
The HDAC3 pathway in LKB1-mutant lung cancer and senescence
This study is looking at how changes in the LKB1 gene affect lung cancer, especially the non-small cell type, and it hopes to find new ways to treat patients by understanding how certain proteins help tumors grow.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10978199 on NIH RePORTER |
What this research studies
This research focuses on understanding how mutations in the LKB1 gene contribute to lung cancer, particularly non-small cell lung cancer (NSCLC). It explores the role of the HDAC3 protein complex in promoting tumor growth and its interaction with other factors that influence cancer cell behavior. By examining the unique biological characteristics of LKB1-mutant tumors, the study aims to identify potential therapeutic targets and improve treatment options for affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with non-small cell lung cancer who have mutations in the LKB1 gene.
Not a fit: Patients with lung cancer who do not have LKB1 mutations may not benefit from the findings of this research.
Why it matters
Potential benefit: If successful, this research could lead to new targeted therapies for patients with LKB1-mutant lung cancer.
How similar studies have performed: Previous research has shown promising results in targeting similar pathways in cancer treatment, indicating potential for success in this area.
Where this research is happening
Chicago, United States
- Northwestern University at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Eichner, Lillian J. — Northwestern University at Chicago
- Study coordinator: Eichner, Lillian J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.