Investigating the role of the gut in multiple joint osteoarthritis in humans and dogs
Is the gut important in multiple joint osteoarthritis? A multimodal investigation in humans and pet dogs
This study is looking at how gut health might affect joint problems in both people and dogs with osteoarthritis, hoping to find new ways to help treat this condition for everyone involved.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-10846695 on NIH RePORTER |
What this research studies
This research explores how increased intestinal permeability may contribute to the development and worsening of multiple joint osteoarthritis (MJOA) in both humans and pet dogs. By studying a large group of human patients alongside dogs that naturally develop MJOA, the research aims to uncover the underlying mechanisms and potential therapies related to this condition. The approach includes analyzing gut health and its impact on joint health, utilizing both human and canine models to gain insights that could lead to better treatment options.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with multiple joint osteoarthritis who may also have gut health issues.
Not a fit: Patients with osteoarthritis limited to a single joint or those without any gastrointestinal concerns may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that improve joint health and reduce pain for patients suffering from multiple joint osteoarthritis.
How similar studies have performed: While the specific approach of combining human and canine models for MJOA is relatively novel, there is existing research indicating that gut health can influence joint conditions.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Nelson, Amanda E — Univ of North Carolina Chapel Hill
- Study coordinator: Nelson, Amanda E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.