Investigating the role of the DEK oncogene in cancer development
New activities of the human DEK oncogene
This study is looking at a gene called DEK that is connected to certain cancers, especially in the head and neck, to see how it affects cancer growth and energy use, with the goal of finding better ways to diagnose and treat patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-10740849 on NIH RePORTER |
What this research studies
This research focuses on the DEK oncogene, which is linked to various cancers, particularly head and neck squamous cell carcinoma (HNSCC). The team aims to understand how DEK influences cancer cell growth and metabolism by regulating important nuclear processes and enzyme activities. By identifying biomarkers and potential drug targets, the research seeks to improve early diagnosis and treatment options for patients with these malignancies. The approach includes studying the interactions between DEK and other oncogenes, as well as its effects on cancer cell bioenergetics.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with head and neck squamous cell carcinoma or other cancers where DEK is implicated.
Not a fit: Patients with cancers unrelated to the DEK oncogene or those who are not diagnosed with any malignancy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new diagnostic tools and targeted therapies for patients with head and neck cancers and other malignancies associated with the DEK oncogene.
How similar studies have performed: Previous studies have shown promising results in understanding the role of oncogenes in cancer, suggesting that this research could build on established findings.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Wells, Susanne I — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Wells, Susanne I
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.