Investigating the role of the Ctr9 gene in addiction to psychostimulants
Functional validation of a role for the candidate gene Ctr9 in psychostimulant action
This study is looking at how a specific gene affects how our bodies react to drugs like amphetamines, using fruit flies and rats to learn more about addiction and find new ways to help people struggling with substance use.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10690002 on NIH RePORTER |
What this research studies
This research explores how the Ctr9 gene influences the body's response to psychostimulants like amphetamines. By studying this gene in fruit flies and rats, researchers aim to understand its role in dopamine neurotransmission and behaviors associated with drug addiction. The study involves genetic manipulation to observe changes in locomotor activity and drug-seeking behavior, which could provide insights into the biological mechanisms of addiction. Ultimately, this research seeks to identify potential targets for new treatments for substance use disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 who may be struggling with addiction to psychostimulants.
Not a fit: Patients who are not affected by substance use disorders or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating psychostimulant addiction.
How similar studies have performed: Previous studies have shown promising results in understanding genetic factors in addiction, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC — New York, United States (Active)
Researchers
- Principal investigator: Javitch, Jonathan a — New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC
- Study coordinator: Javitch, Jonathan a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.