Investigating the role of the ASH1L gene in autism spectrum disorders
Official title: ASH1L mediated transcription networks in autism spectrum disorders
Funded at Brown University · NIH-10993587 · Data updated 2026-11-12
This study is looking at how a specific gene called ASH1L affects brain cell development in people with autism, hoping to find new ways to help manage the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brown University NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $730,724 |
| NIH project number | 5R01MH127081-04 |
| Project ID | NIH-10993587 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with autism spectrum disorders, particularly those with a family history of genetic mutations related to ASH1L.
✕Less likely to help
Patients without a diagnosis of autism spectrum disorders or those whose conditions are unrelated to genetic factors may not benefit from this research.
What this research studies
This research focuses on understanding how the ASH1L gene influences the development and function of neurons in individuals with autism spectrum disorders (ASD). By examining the interactions between ASH1L and other high-risk genes, the study aims to uncover the molecular mechanisms that contribute to ASD. The researchers will utilize both human and mouse models to explore how ASH1L regulates important neuronal processes, which could lead to new treatment strategies. This approach combines genetic analysis with advanced techniques to provide insights into the underlying biology of ASD.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic targets for treating autism spectrum disorders.
How similar studies have gone: Previous research has shown promising results in understanding genetic factors in autism, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Brown University
Providence, United States Active
Researchers
- Principal investigator: Lizarraga, Sofia Beatriz — Brown University
- Study coordinator: Lizarraga, Sofia Beatriz
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.