Investigating the role of the ASH1L gene in autism spectrum disorder
Official title: Epigenetic mechanisms of histone methyltransferase ASH1L in autism spectrum disorder
Funded at Michigan State University · NIH-11064868 · Data updated 2026-11-12
This study is looking at how changes in a specific gene called ASH1L might be linked to autism, using mice to see how these changes affect brain function and behavior, with the hope of finding new treatments to help improve the lives of people with autism.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michigan State University NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project start | June 15, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $440,496 |
| NIH project number | 5R01MH130544-03 |
| Project ID | NIH-11064868 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years who have been diagnosed with autism spectrum disorder, particularly those with identified ASH1L mutations.
✕Less likely to help
Patients who do not have autism spectrum disorder or those without ASH1L mutations may not benefit from this research.
What this research studies
This research explores how mutations in the ASH1L gene may contribute to autism spectrum disorder (ASD) by examining the effects of these mutations in a mouse model. The study focuses on understanding the mechanisms by which ASH1L influences brain function and behavior, particularly looking at neural signaling imbalances that may lead to autistic-like behaviors. Researchers will also investigate potential treatments that target these genetic pathways to improve cognitive and behavioral outcomes in affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for children with autism spectrum disorder.
How similar studies have gone: Previous research has shown promising results in understanding the genetic basis of autism and the role of histone modifications, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Michigan State University
East Lansing, United States Active
Researchers
- Principal investigator: He, Jin — Michigan State University
- Study coordinator: He, Jin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.