Investigating the role of tetraspanin proteins in immune and brain health
Structure and Function of Tetraspanin Complexes
This study is looking at special proteins called tetraspanins, which are important for our immune system and brain health, to help us understand how they work and how they might lead to new treatments for diseases like Alzheimer's and immune disorders.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard Medical School NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10885983 on NIH RePORTER |
What this research studies
This research focuses on understanding the structure and function of tetraspanin proteins, particularly CD81 and the C8 subfamily, which play crucial roles in immune responses and brain health. The study aims to uncover how these proteins interact with B cell receptors and other cellular components, which is essential for developing new therapies for conditions like Alzheimer's disease and immune disorders. By exploring the mechanisms of tetraspanins, the research seeks to fill critical knowledge gaps that could lead to innovative treatment strategies. Patients may benefit from insights gained about how these proteins influence disease processes.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or related dementias, as well as those with immune system disorders.
Not a fit: Patients with conditions unrelated to immune function or Alzheimer's disease may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches for Alzheimer's disease and related conditions.
How similar studies have performed: Previous research has shown promising results in understanding the roles of tetraspanins in various diseases, indicating potential for success in this area.
Where this research is happening
Boston, United States
- Harvard Medical School — Boston, United States (Active)
Researchers
- Principal investigator: Blacklow, Stephen C. — Harvard Medical School
- Study coordinator: Blacklow, Stephen C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.