Investigating the role of TET1 in the development of non-alcoholic fatty liver disease
TET1 in non-alcoholic fatty liver disease development
This study is looking at how a protein called TET1 affects non-alcoholic fatty liver disease (NAFLD) and aims to find out how it relates to inflammation and liver damage, which could help develop new treatments for people with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tulane University of Louisiana NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project ID | NIH-11015818 on NIH RePORTER |
What this research studies
This research aims to explore how the TET1 protein influences the development and progression of non-alcoholic fatty liver disease (NAFLD). It focuses on understanding the relationship between DNA methylation, inflammation, and fibrosis in patients with NAFLD. By studying specific genes associated with this condition, the research seeks to uncover the biochemical mechanisms that contribute to fatty liver disease. Patients may benefit from insights that could lead to new treatment strategies targeting TET1 and its role in liver health.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults over 21 years old who are diagnosed with non-alcoholic fatty liver disease.
Not a fit: Patients with alcoholic liver disease or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches for preventing or treating non-alcoholic fatty liver disease.
How similar studies have performed: Previous studies have shown promising results in understanding the role of DNA methylation in liver diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
New Orleans, United States
- Tulane University of Louisiana — New Orleans, United States (Active)
Researchers
- Principal investigator: Huang, Chiung-Kuei — Tulane University of Louisiana
- Study coordinator: Huang, Chiung-Kuei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.