Investigating the role of TEAD1 in heart health and disease
Tead1 and Cardiac Adaptation
This study is looking at how a protein called TEAD1 affects how our hearts work, especially when they’re under stress or hurt, to help find new ways to treat heart problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10652349 on NIH RePORTER |
What this research studies
This research focuses on understanding how the TEAD1 protein influences heart function and adaptation, particularly in response to stress and injury. By examining the interactions between TEAD1 and other proteins involved in heart cell growth and survival, the study aims to uncover the mechanisms that lead to heart hypertrophy and failure. The researchers will utilize advanced molecular techniques to analyze gene expression and cellular behavior in heart cells, providing insights into potential therapeutic targets for heart disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults experiencing heart-related issues, particularly those with conditions leading to cardiac hypertrophy or heart failure.
Not a fit: Patients with non-cardiac related health issues or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart function and prevent heart failure in patients.
How similar studies have performed: Previous research has shown promising results in understanding the role of TEAD proteins in heart health, indicating that this approach could yield valuable insights.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Moulik, Mousumi — University of Pittsburgh at Pittsburgh
- Study coordinator: Moulik, Mousumi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.