Investigating the role of TDP43 protein in brain function and neurodegenerative diseases
Official title: Synaptic TDP43 in the Adult Mouse Brain
Funded at Columbia University Health Sciences · NIH-11075555 · Data updated 2026-11-12
This study is looking at how a protein called TDP43, which builds up in the brains of people with Alzheimer's and ALS, affects thinking and memory, hoping to find new ways to help treat these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $49,974 |
| NIH project number | 1F99NS141397-01 |
| Project ID | NIH-11075555 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Alzheimer's Disease, Frontotemporal Dementia, or Amyotrophic Lateral Sclerosis.
✕Less likely to help
Patients with neurodegenerative diseases not related to TDP43 dysfunction may not benefit from this research.
What this research studies
This research focuses on understanding how the TDP43 protein, which accumulates abnormally in various neurological disorders, affects cognitive function in conditions like Alzheimer's Disease and Amyotrophic Lateral Sclerosis. By using advanced techniques to analyze TDP43 interactions in the brains of mouse models, the study aims to uncover the molecular mechanisms that contribute to cognitive impairment. The findings could lead to new insights into how these diseases progress and potentially identify targets for therapeutic intervention.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients suffering from neurodegenerative diseases.
How similar studies have gone: Previous research has shown promising results in understanding TDP43's role in neurodegeneration, indicating that this approach may yield valuable insights.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Brewer, Elizabeth Moran — Columbia University Health Sciences
- Study coordinator: Brewer, Elizabeth Moran
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.