Investigating the role of TDP-43 protein in Alzheimer's disease and related dementias
Stathmin-2 and TDP-43 neurodegeneration in Alzheimer’s and multi-etiology dementias
This study is looking at how a protein called TDP-43 might play a role in memory problems and brain changes in people with Alzheimer's and other types of dementia, with the hope of finding new ways to help improve their condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11087654 on NIH RePORTER |
What this research studies
This research focuses on understanding how the TDP-43 protein contributes to neurodegeneration in Alzheimer's disease and other types of dementia. Researchers will examine the relationship between TDP-43 levels and various cognitive impairments, as well as brain changes over time. By analyzing brain samples and patient data, the study aims to uncover the mechanisms by which TDP-43 affects memory and brain structure, potentially leading to new therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or other forms of dementia who may have TDP-43 protein involvement.
Not a fit: Patients with dementia not associated with TDP-43 or those with other unrelated neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with Alzheimer's disease and related dementias.
How similar studies have performed: Previous research has shown promising results in understanding the role of TDP-43 in neurodegeneration, indicating that this approach has potential for significant findings.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Josephs, Keith a — Mayo Clinic Rochester
- Study coordinator: Josephs, Keith a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.