Investigating the role of TCF7L2 in heart failure and hypertrophy
TCF7L2 Insoforms in Canonical Wnt Signaling During Cardiac Hpertrophy & Failure
This study is looking at how certain proteins in the heart affect its function, with the hope of finding new ways to treat heart failure, so that patients can have better options for managing their heart health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-11059899 on NIH RePORTER |
What this research studies
This research focuses on understanding the molecular mechanisms behind heart failure, particularly how certain proteins, known as TCF7L2 isoforms, influence heart function. By examining human heart tissues and creating mouse models, the study aims to uncover how these proteins interact with other signaling pathways to affect heart health. The goal is to identify specific gene targets that could lead to new therapies for heart failure. Patients may benefit from insights that could lead to more effective treatments for heart conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults with heart failure or those at risk of developing heart-related conditions.
Not a fit: Patients with heart conditions unrelated to the mechanisms being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies for heart failure, improving patient outcomes.
How similar studies have performed: Previous research has shown that targeting molecular pathways like Wnt/β-catenin can lead to significant advancements in understanding heart disease, suggesting potential for success in this area.
Where this research is happening
San Antonio, United States
- University of Texas Hlth Science Center — San Antonio, United States (Active)
Researchers
- Principal investigator: Li, Faqian — University of Texas Hlth Science Center
- Study coordinator: Li, Faqian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.