Investigating the role of tau protein in early Alzheimer's disease
Multimodal investigation of tau-related vasculopathy in prodromal Alzheimer's disease
This study is looking at how a protein called tau impacts blood flow and brain function in people who are showing early signs of Alzheimer's, with the goal of finding better ways to diagnose and treat those at risk.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11076224 on NIH RePORTER |
What this research studies
This research focuses on understanding how tau protein affects blood flow and brain function in individuals with early signs of Alzheimer's disease. Using advanced imaging techniques like MRI and PET scans, the study aims to explore the relationship between tau deposition and changes in cerebral blood flow and vascular function over time. By measuring these factors, researchers hope to uncover the mechanisms behind cognitive decline associated with Alzheimer's, particularly in its prodromal stages. This could lead to better diagnostic tools and treatment strategies for patients at risk of developing Alzheimer's.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals showing early signs of Alzheimer's disease, particularly those with tau protein accumulation.
Not a fit: Patients with advanced Alzheimer's disease or those without any cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of Alzheimer's disease, potentially enhancing early diagnosis and treatment options.
How similar studies have performed: Previous research has shown promising results in understanding tau pathology and its implications in Alzheimer's disease, indicating that this approach is building on established findings.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Jahanian, Hesamoddin — University of Washington
- Study coordinator: Jahanian, Hesamoddin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.