Investigating the role of tau protein in brain development and disorders.
Official title: A non-canonical role for tau in early human brain development
Funded at University of Iowa · NIH-11079594 · Data updated 2026-11-12
This study is looking at how a protein called tau, which is linked to Alzheimer's disease, also plays a role in brain development and disorders like autism and epilepsy, with the hope of finding new treatments that could help kids with these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project start | May 1, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $490,349 |
| NIH project number | 5R01NS136448-02 |
| Project ID | NIH-11079594 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals under 21 years old with autism, epilepsy, or those who have experienced early-life brain injuries.
✕Less likely to help
Patients with neurodevelopmental disorders not related to tau protein dysfunction may not benefit from this research.
What this research studies
This research explores how the tau protein, known for its involvement in Alzheimer's disease, also affects brain development and disorders such as autism and epilepsy. By studying tau's functions in human models, the research aims to understand its role in neuronal network dysfunction and how it contributes to conditions resulting from brain injuries. The approach includes examining tau's interactions and effects on brain cells, which could lead to new therapeutic strategies for neurodevelopmental disorders. The ultimate goal is to adapt existing Alzheimer treatments for use in these conditions, ensuring safety and efficacy in young patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for neurodevelopmental disorders, improving the quality of life for affected individuals.
How similar studies have gone: Previous research has shown promise in targeting tau for Alzheimer's treatment, suggesting potential for success in similar neurodevelopmental contexts.
Where this research is happening
-
University of Iowa
Iowa City, United States Active
Researchers
- Principal investigator: Hefti, Marco Matthias — University of Iowa
- Study coordinator: Hefti, Marco Matthias
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.