Investigating the role of T cells in Alzheimer's disease
The role of brain resident T cells in Alzheimer's disease
This study is looking at how a special type of immune cell called tissue resident memory T cells might affect the progression of Alzheimer's disease, and it aims to see if activating these cells can help us understand more about the immune response in Alzheimer's and how it could lead to new treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dartmouth College NIH-funded |
| Lab location | 1 site (Hanover, United States) |
| Project ID | NIH-11094831 on NIH RePORTER |
What this research studies
This research explores how T cells, a type of immune cell, may influence the progression of Alzheimer's disease (AD). The study focuses on a specific group of T cells known as tissue resident memory T cells (TRM), which are found in the brain and may play a crucial role in responding to the disease. By using a model antigen, the researchers aim to activate these T cells and observe their effects on AD progression. This innovative approach seeks to provide insights into the immune response in Alzheimer's and its potential implications for treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk of developing it.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that harness the immune system to combat Alzheimer's disease.
How similar studies have performed: While the role of T cells in Alzheimer's is an emerging field, this specific approach to studying tissue resident memory T cells in the context of AD is novel and has not been extensively tested.
Where this research is happening
Hanover, United States
- Dartmouth College — Hanover, United States (Active)
Researchers
- Principal investigator: Rosato, Pamela — Dartmouth College
- Study coordinator: Rosato, Pamela
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.