Investigating the role of STING in lysosomal storage disorders
Official title: The Role of Sting in Lysosomal Storage Disorder
Funded at Ut Southwestern Medical Center · NIH-11109683 · Data updated 2026-11-12
This study is looking at how a specific immune pathway called STING works in people with lysosomal storage disorders, and it hopes to find out if blocking this pathway can help reduce inflammation and slow down the disease, which could lead to new treatments.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | June 6, 2024 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $197,468 |
| NIH project number | 5R21AI185226-02 |
| Project ID | NIH-11109683 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with lysosomal storage disorders, particularly those experiencing early-onset neurodegeneration.
✕Less likely to help
Patients with lysosomal storage disorders who do not exhibit inflammation or neurodegeneration may not benefit from this research.
What this research studies
This research focuses on lysosomal storage disorders (LSD), which are genetic diseases caused by mutations affecting lysosomal enzymes. The study aims to understand how the STING immune signaling pathway is activated in these disorders, particularly in relation to inflammation and neurodegeneration. Using mouse models, researchers will explore whether inhibiting STING can reduce inflammation and disease progression. The goal is to identify STING as a potential target for new therapies in treating LSD.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that alleviate inflammation and improve outcomes for patients with lysosomal storage disorders.
How similar studies have gone: Previous research has shown promise in targeting immune pathways in similar conditions, suggesting that this approach could be effective.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Yan, Nan — Ut Southwestern Medical Center
- Study coordinator: Yan, Nan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.