Investigating the role of STEAP4 in eye disease related to diabetes
Official title: The role of STEAP4 in retinal pathogenesis and diabetic retinopathy
Funded at Louis Stokes Cleveland VA Medical Center · NIH-10923555 · Data updated 2026-11-12
This study is looking at how a specific enzyme called STEAP4 affects eye health in people with diabetes, especially those dealing with vision problems, to help find new ways to treat diabetic retinopathy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Louis Stokes Cleveland VA Medical Center NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| NIH project number | 1I01BX006424-01A1 |
| Project ID | NIH-10923555 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with diabetes who are experiencing or at risk of developing diabetic retinopathy.
✕Less likely to help
Patients without diabetes or those who do not have any signs of diabetic retinopathy may not benefit from this research.
What this research studies
This research focuses on understanding how STEAP4, a metabolic enzyme, contributes to diabetic retinopathy, a serious eye condition affecting many individuals with diabetes. The study will explore the mechanisms by which STEAP4 influences inflammation, oxidative stress, and iron accumulation in the retina, which are critical factors in the disease's progression. By examining the effects of STEAP4 on cell damage and visual function, the research aims to uncover new therapeutic targets for treating diabetic retinopathy. Patients with diabetes who are experiencing vision problems may find this research particularly relevant.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve vision and quality of life for patients suffering from diabetic retinopathy.
How similar studies have gone: Previous research has shown promising results in targeting metabolic pathways related to diabetic retinopathy, suggesting that this approach could yield significant advancements.
Where this research is happening
-
Louis Stokes Cleveland VA Medical Center
Cleveland, United States Active
Researchers
- Principal investigator: Taylor, Patricia R — Louis Stokes Cleveland VA Medical Center
- Study coordinator: Taylor, Patricia R
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.