Investigating the role of specific RNA molecules in asthma
tRNA-derived non-coding RNAs in ASM function and in asthma
This study is looking at tiny molecules in our cells that might play a role in asthma, with the hope of finding new ways to improve treatments for people living with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Thomas Jefferson University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10643968 on NIH RePORTER |
What this research studies
This research focuses on understanding how short non-coding RNAs (ncRNAs) contribute to the development and progression of asthma, a chronic inflammatory disease affecting the airways. The study aims to identify the expression profiles and functions of these ncRNAs, particularly those that are not typically detected by standard RNA sequencing methods. By examining how inflammatory mediators influence airway cells, the research seeks to uncover new regulatory mechanisms that could lead to better treatments for asthma. Patients may benefit from insights gained into the molecular processes underlying their condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with asthma, particularly those experiencing severe symptoms or frequent exacerbations.
Not a fit: Patients with asthma who have not responded to any treatments or those with other unrelated respiratory conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing asthma more effectively.
How similar studies have performed: Previous research has shown promise in understanding the role of non-coding RNAs in various diseases, suggesting that this approach could yield valuable insights into asthma as well.
Where this research is happening
Philadelphia, United States
- Thomas Jefferson University — Philadelphia, United States (Active)
Researchers
- Principal investigator: Kirino, Yohei — Thomas Jefferson University
- Study coordinator: Kirino, Yohei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.