Investigating the role of specific proteins in thoracic aortic aneurysms
Official title: Roles of Fibrillin-1 and Fibronectin in Thoracic Aortopathy - Adhesion Receptor Signaling
Funded at Yale University · NIH-11015433 · Data updated 2026-11-12
This study is looking at how specific proteins in your body might play a role in the development of thoracic aortic aneurysms, with the hope that understanding these proteins better could lead to new ways to treat or prevent this condition.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | January 15, 2025 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $358,299 |
| NIH project number | 1P01HL169168-01A1 |
| Project ID | NIH-11015433 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a family history of thoracic aortic aneurysms or those diagnosed with related aortic diseases.
✕Less likely to help
Patients without genetic predispositions to aortic diseases or those with unrelated cardiovascular conditions may not benefit from this research.
What this research studies
This research focuses on understanding how certain proteins, specifically fibrillin-1 and fibronectin, contribute to the development of thoracic aortic aneurysms. By examining the genetic variants that affect these proteins and their interactions within the aortic wall, the study aims to uncover the mechanisms that lead to aneurysm formation. The approach involves analyzing how changes in the extracellular matrix and vascular smooth muscle cells impact the structural integrity of the aorta. Patients may benefit from insights that could lead to new treatment strategies or preventive measures for aortic diseases.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of thoracic aortic aneurysms, potentially reducing the risk of life-threatening complications.
How similar studies have gone: Previous research has shown promising results in understanding the role of extracellular matrix proteins in vascular diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Schwartz, Martin a — Yale University
- Study coordinator: Schwartz, Martin a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.