Investigating the role of specific proteins in mouse eye cells
Official title: Conditional knock-in of Gnb3/Gngt2 in mouse rod photoreceptors
Funded at Saint Louis University · NIH-10952511 · Data updated 2026-11-12
This study is looking at how a specific protein in the eyes of mice affects vision, with the goal of learning more about eye problems and helping to find better treatments for people with vision issues.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Saint Louis University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $151,500 |
| NIH project number | 1R03TR005223-01 |
| Project ID | NIH-10952511 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic mutations affecting vision, particularly those related to GNB3.
✕Less likely to help
Patients with visual impairments not linked to genetic mutations in GNB3 may not benefit from this research.
What this research studies
This research focuses on understanding how certain proteins, specifically the G-protein Gb3 subunit, function in the retinal cells of mice. By creating a unique mouse model that replaces a specific protein complex in rod photoreceptors with its cone counterpart, the researchers aim to uncover the mechanisms behind visual impairment and other related conditions. The study will collect preliminary data that could lead to a deeper understanding of retinal signaling and the impact of genetic mutations on vision. This research could ultimately inform future treatments for retinal disorders.
Why it matters
Potential benefit: If successful, this research could lead to new insights and potential therapies for patients suffering from visual impairments and related genetic disorders.
How similar studies have gone: While this approach is novel in its specific focus on GNB3 in retinal cells, similar studies have shown promise in understanding genetic contributions to visual disorders.
Where this research is happening
-
Saint Louis University
Saint Louis, United States Active
Researchers
- Principal investigator: Kisselev, Oleg G — Saint Louis University
- Study coordinator: Kisselev, Oleg G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.