Investigating the role of specific proteins in mantle cell lymphoma
Role of ubiquitin ligases in mantle cell lymphoma
This study is looking into how a specific protein called UBR5 affects the growth of mantle cell lymphoma, a rare type of blood cancer, to find new ways to help patients with this condition.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-11063058 on NIH RePORTER |
What this research studies
This research focuses on understanding the molecular mechanisms behind mantle cell lymphoma (MCL), a rare and aggressive form of non-Hodgkin's lymphoma. The study specifically examines the role of ubiquitin E3 ligases, particularly UBR5, in the development and progression of MCL. Using advanced techniques like CRISPR/Cas9, researchers are creating mouse models to explore how mutations in UBR5 affect B-lymphocyte development and the overall disease process. By analyzing these mechanisms, the research aims to identify potential new therapeutic targets for MCL patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with mantle cell lymphoma, particularly those with specific genetic mutations.
Not a fit: Patients with other types of lymphoma or those without the relevant genetic mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel treatments for mantle cell lymphoma, improving outcomes for patients.
How similar studies have performed: Previous research has shown promising results in targeting similar molecular pathways in other types of cancers, suggesting potential for success in this area as well.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Buckley, Shannon — University of Utah
- Study coordinator: Buckley, Shannon
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.