Investigating the role of specific proteins in lung injury caused by sepsis
PAD2 and CitH3 in Pathogenesis of Sepsis-induced ALI
This study is looking at how sepsis can cause lung problems and is exploring specific proteins that might help us find better ways to treat patients who are dealing with lung damage from infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10909894 on NIH RePORTER |
What this research studies
This research focuses on understanding how sepsis, a severe response to infection, leads to acute lung injury (ALI). It examines the role of proteins called citrullinated histone H3 (CitH3) and peptidylarginine deiminase 2 (PAD2) in the development of ALI. By studying animal models and analyzing patient samples, the research aims to identify potential biomarkers and therapeutic targets that could improve outcomes for patients suffering from sepsis-induced lung damage.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with sepsis who are experiencing acute lung injury.
Not a fit: Patients with acute lung injury from non-infectious causes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce lung injury and improve survival rates for patients with sepsis.
How similar studies have performed: Previous research has shown promising results in targeting similar pathways in animal models, suggesting potential for success in this approach.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Li, Yongqing — University of Michigan at Ann Arbor
- Study coordinator: Li, Yongqing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.