Investigating the role of specific proteins in liver inflammation caused by alcohol.
Official title: IRAKM and MINCLE in ALD
Funded at Cleveland Clinic Lerner Com-Cwru · NIH-10909306 · Data updated 2026-11-12
This study is looking at how drinking alcohol can cause liver inflammation in people with alcoholic liver disease, and it hopes to find new ways to help treat this condition by understanding how certain proteins in the liver react to cell damage.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | August 17, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $602,163 |
| NIH project number | 5R01AA030699-02 |
| Project ID | NIH-10909306 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with alcoholic liver disease who are experiencing liver inflammation.
✕Less likely to help
Patients with liver inflammation due to causes other than alcohol consumption may not benefit from this research.
What this research studies
This research focuses on understanding how liver inflammation develops in patients with alcoholic liver disease (ALD), which can lead to severe complications like fibrosis and cancer. The study examines the mechanisms by which cell death in the liver, triggered by alcohol consumption, activates inflammatory responses. By exploring the role of certain proteins and their interactions in this process, the research aims to identify new therapeutic targets that could improve treatment options for patients suffering from ALD.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that more effectively manage liver inflammation in patients with alcoholic liver disease.
How similar studies have gone: Previous research has shown promising results in understanding inflammatory mechanisms in liver diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Cleveland Clinic Lerner Com-Cwru
Cleveland, United States Active
Researchers
- Principal investigator: Nagy, Laura E. — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Nagy, Laura E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.