Investigating the role of specific proteins in kidney disease related to Tuberous Sclerosis Complex.
Role of TFEB and TFE3 in Tuberous Sclerosis Complex (TSC) Kidney Disease
This study is looking at how certain proteins affect kidney problems in people with Tuberous Sclerosis Complex, with the hope of finding better treatments that could help improve kidney health and reduce the need for long-term medication.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11118807 on NIH RePORTER |
What this research studies
This research focuses on understanding how the proteins TFEB and TFE3 contribute to kidney disease in patients with Tuberous Sclerosis Complex (TSC). By studying the effects of these proteins on kidney tumors and other related conditions, the research aims to identify new therapeutic strategies that could improve patient outcomes. The approach includes analyzing cellular mechanisms and utilizing animal models to observe the impact of these proteins on tumor growth and kidney function. The ultimate goal is to find more effective treatments that could reduce the need for lifelong therapy.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Tuberous Sclerosis Complex, particularly those experiencing kidney-related complications.
Not a fit: Patients without Tuberous Sclerosis Complex or those not experiencing kidney issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel therapies that effectively eliminate kidney tumors associated with Tuberous Sclerosis Complex.
How similar studies have performed: Previous research has shown promising results in targeting similar pathways in other conditions, suggesting potential for success in this novel approach.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Henske, Elizabeth P — Brigham and Women's Hospital
- Study coordinator: Henske, Elizabeth P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.