Investigating the role of specific protein aggregates in Lewy body dementia
Functional assessment of pathological α-syn and Aβ species in LBD
This study is looking at how certain proteins in the brain are linked to Lewy body dementia, with the hope of finding better ways to diagnose and treat the condition, so that patients can have more effective care.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Jacksonville NIH-funded |
| Lab location | 1 site (Jacksonville, United States) |
| Project ID | NIH-10686906 on NIH RePORTER |
What this research studies
This research focuses on understanding the mechanisms behind Lewy body dementia by examining changes in brain tissue associated with the disease. It aims to identify specific forms of alpha-synuclein and beta-amyloid proteins that contribute to neurotoxicity and the progression of symptoms. By analyzing post-mortem brain samples, the study will compare different protein aggregates and explore how they may spread between cells, potentially leading to new diagnostic and treatment strategies. Patients may benefit from insights gained into the disease's pathology and the development of targeted therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Lewy body dementia or those exhibiting symptoms related to the condition.
Not a fit: Patients with other forms of dementia not related to Lewy body pathology may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostics and treatments for Lewy body dementia.
How similar studies have performed: Previous research has shown promise in understanding protein aggregation in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Jacksonville, United States
- Mayo Clinic Jacksonville — Jacksonville, United States (Active)
Researchers
- Principal investigator: Mclean, Pamela J — Mayo Clinic Jacksonville
- Study coordinator: Mclean, Pamela J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.