Investigating the role of specific progenitor cells in the development of the jaw joint.
Official title: Role of LGR+ connective tissue progenitors in TMJ development
Funded at University of Southern California · NIH-11136274 · Data updated 2026-11-12
This study is looking at how certain cells help build the jaw joint, which is important for how we move our jaws, and it aims to find out more about the causes of jaw problems in kids so we can develop better treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project start | July 15, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $496,320 |
| NIH project number | 5R01DE033893-02 |
| Project ID | NIH-11136274 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research are children aged 0-11 years who are experiencing TMJ disorders.
✕Less likely to help
Patients with TMJ disorders who are older than 11 years may not receive direct benefits from this research.
What this research studies
This research focuses on understanding how certain progenitor cells contribute to the development of the temporomandibular joint (TMJ), which is crucial for jaw function. By utilizing advanced techniques such as single-cell analysis and genetic studies in zebrafish and mice, the researchers aim to identify the specific stem cells responsible for forming the connective tissues in the TMJ. This could help clarify the developmental origins of TMJ disorders, particularly in children, and may lead to new therapeutic strategies. The study seeks to uncover the mechanisms that ensure the correct formation of these tissues during development.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for children suffering from TMJ disorders.
How similar studies have gone: Previous research has shown promising results in understanding the roles of progenitor cells in other developmental contexts, suggesting potential for success in this area as well.
Where this research is happening
-
University of Southern California
Los Angeles, United States Active
Researchers
- Principal investigator: Crump, Gage D — University of Southern California
- Study coordinator: Crump, Gage D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.