Investigating the role of specific NMDA receptors in brain signaling
Official title: Physiology and pharmacology of GluN3-containing NMDA receptors
Funded at University of Montana · NIH-10997378 · Data updated 2026-11-12
This study is looking into a special type of brain receptor that might play a role in neurological disorders, to help us understand how it works and possibly find new treatments for conditions related to it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Montana NIH-funded |
| Lab location | 1 site (Missoula, United States) |
| Project start | March 1, 2021 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $329,400 |
| NIH project number | 5R01NS116055-05 |
| Project ID | NIH-10997378 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with central nervous system disorders that may be linked to NMDA receptor dysfunction.
✕Less likely to help
Patients with conditions unrelated to NMDA receptor activity or those who do not have central nervous system disorders may not benefit from this research.
What this research studies
This research focuses on understanding the physiology and pharmacology of a specific type of NMDA receptor that contains the GluN3 subunit, which is less understood compared to other NMDA receptors. The researchers aim to explore how these receptors function in the central nervous system and their potential involvement in various neurological disorders. By using advanced techniques like electrophysiological recordings, they will assess the properties of these receptors and their role in neuronal signaling. This could lead to the development of targeted therapies for conditions linked to these receptors.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for central nervous system disorders by targeting GluN3-containing NMDA receptors.
How similar studies have gone: While the specific focus on GluN3-containing NMDA receptors is relatively novel, similar research on other NMDA receptor subtypes has shown promising results in understanding their roles in brain function.
Where this research is happening
-
University of Montana
Missoula, United States Active
Researchers
- Principal investigator: Hansen, Kasper Boe — University of Montana
- Study coordinator: Hansen, Kasper Boe
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.