Investigating the role of specific molecules in the development of adenomyosis.
Official title: REST/NRSF, miRNAs, and tissue remodeling in adenomyosis pathophysiology
Funded at University of Kansas Medical Center · NIH-11085179 · Data updated 2026-11-12
This study is looking into adenomyosis, a condition that causes pain and problems with pregnancy, to find out how certain molecules in the body affect it, which could help create new, less invasive treatments for those who suffer from it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kansas Medical Center NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project start | August 9, 2021 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $611,887 |
| NIH project number | 5R01HD105714-05 |
| Project ID | NIH-11085179 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women diagnosed with adenomyosis who experience symptoms such as heavy menstrual bleeding, pelvic pain, or reproductive dysfunction.
✕Less likely to help
Patients who do not have adenomyosis or those who have already undergone a hysterectomy may not benefit from this research.
What this research studies
This research focuses on understanding adenomyosis, a condition where endometrial tissue grows into the uterine muscle, causing significant pain and reproductive issues. By examining human tissue samples and using innovative mouse models, the study aims to uncover the biological mechanisms behind this condition, particularly the roles of REST and miRNAs in tissue remodeling. The research will involve various laboratory techniques to identify how these molecules contribute to the disease's development, which could lead to new treatment options. Patients may benefit from a better understanding of adenomyosis and potential new therapies that are less invasive than current options.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for women suffering from adenomyosis, reducing pain and enhancing reproductive health.
How similar studies have gone: While the specific approach of this research is novel, previous studies have shown promise in understanding adenomyosis through similar biological mechanisms.
Where this research is happening
-
University of Kansas Medical Center
Kansas City, United States Active
Researchers
- Principal investigator: Nothnick, Warren B — University of Kansas Medical Center
- Study coordinator: Nothnick, Warren B
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.