Investigating the role of specific lipids in kidney disease related to diabetes and obesity
Official title: Role of Glycosphingolipids in Kidney Disease in Diabetes and Obesity
Funded at Georgetown University · NIH-11049524 · Data updated 2026-11-12
This study is looking at how certain fats in the body might affect kidney health in people with diabetes and obesity, and it aims to see if blocking these fats can help keep kidneys healthier.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgetown University NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project start | January 20, 2025 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $830,500 |
| NIH project number | 1R01DK139676-01A1 |
| Project ID | NIH-11049524 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from diabetes and obesity who are at risk for chronic kidney disease.
✕Less likely to help
Patients without diabetes or obesity, or those with other unrelated kidney conditions, may not benefit from this research.
What this research studies
This research focuses on understanding how certain lipids, specifically glycosphingolipids, contribute to kidney disease in individuals with diabetes and obesity. The researchers will use mouse models to explore how increasing levels of these lipids affect kidney function and inflammation. By inhibiting the synthesis of these lipids, they aim to determine if this can prevent the progression of kidney disease. Advanced techniques will be employed to analyze lipid composition and cellular changes in the kidneys.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or slow the progression of kidney disease in patients with diabetes and obesity.
How similar studies have gone: Other research has shown promising results in targeting lipid metabolism for improving kidney health, suggesting that this approach may be effective.
Where this research is happening
-
Georgetown University
Washington, United States Active
Researchers
- Principal investigator: Levi, Moshe — Georgetown University
- Study coordinator: Levi, Moshe
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.