Investigating the role of specific lipids in diabetic nerve damage
Role of Complex Sphingolipids in Diabetic Neuropathy
This study is looking at how certain fats in the body might be causing nerve pain in people with diabetes, and it hopes to find new ways to help manage this pain by exploring the role of specific amino acids.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10848314 on NIH RePORTER |
What this research studies
This research focuses on understanding diabetic neuropathy, a painful condition affecting many individuals with diabetes. It aims to identify the specific molecules involved in the accumulation of neurotoxic lipids that may contribute to nerve damage. By examining the relationship between certain amino acids and these lipids, the study seeks to uncover potential therapeutic targets. The research utilizes advanced mass spectrometry techniques to analyze lipid levels in patients, which could lead to new treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with diabetes who are experiencing symptoms of neuropathy.
Not a fit: Patients without diabetes or those who do not exhibit symptoms of neuropathy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that alleviate or prevent nerve damage in people with diabetes.
How similar studies have performed: Previous research has shown promising results in animal models regarding the role of lipid metabolism in diabetic neuropathy, indicating potential for success in this area.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Fridman, Vera — University of Colorado Denver
- Study coordinator: Fridman, Vera
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.