Investigating the role of specific kinases in cancer development and treatment
Cyclin C-CDK8/19 kinases in development and in cancer
This study is looking at certain proteins that help control how genes work and are connected to cancer, to see if new treatments using small drugs can slow down tumor growth, which could help patients with cancer in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dana-Farber Cancer Inst NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11064028 on NIH RePORTER |
What this research studies
This research focuses on the cyclin C-CDK8/19 kinases, which are involved in regulating gene transcription and have been linked to cancer progression. By studying how these kinases function and their role in various tumor types, the research aims to identify potential therapeutic targets for cancer treatment. The approach includes using small molecule inhibitors to assess their effectiveness in reducing tumor growth in preclinical models. Patients may benefit from new treatment strategies that target these kinases if successful.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with cancers that show overexpression of cyclin C, CDK8, or CDK19.
Not a fit: Patients with cancers not associated with the cyclin C-CDK8/19 pathway may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new targeted therapies for cancer patients, improving treatment outcomes.
How similar studies have performed: Previous research has shown promising results with similar approaches targeting cyclin-dependent kinases in cancer treatment.
Where this research is happening
Boston, United States
- Dana-Farber Cancer Inst — Boston, United States (Active)
Researchers
- Principal investigator: Sicinski, Peter — Dana-Farber Cancer Inst
- Study coordinator: Sicinski, Peter
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.