Investigating the role of specific immune cells in gut inflammation
Role of membrane-associated macrophages in health and inflammation
This study is looking at special immune cells in the gut to see how they work and change when there's inflammation, which could help us understand conditions like mesenteritis and find new ways to improve gut health for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project ID | NIH-10991675 on NIH RePORTER |
What this research studies
This research focuses on understanding how certain immune cells, known as membrane-associated macrophages, function in the gut and how they are affected by inflammation. By examining these cells in detail, the researchers aim to uncover their roles in both healthy and inflamed states of the gut, particularly in conditions like mesenteritis. The study employs genetic analysis and other methodologies to explore how these macrophages interact with their environment and contribute to gut health. Patients may benefit from insights gained about the mechanisms of gut inflammation and potential new therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults experiencing gut inflammation or related disorders, such as mesenteritis or inflammatory bowel disease.
Not a fit: Patients with non-inflammatory gastrointestinal conditions or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for gut inflammatory conditions, enhancing patient outcomes.
How similar studies have performed: Previous research has shown promise in understanding immune cell roles in inflammation, suggesting that this approach could yield valuable insights.
Where this research is happening
Chicago, UNITED STATES
- University of Illinois at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Kim, Kiwook — University of Illinois at Chicago
- Study coordinator: Kim, Kiwook
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.